Nonlinear effects of noradrenergic modulation of olfactory bulb function in adult rodents.
نویسندگان
چکیده
The mammalian main olfactory bulb receives a significant noradrenergic input from the locus coeruleus. Norepinephrine (NE) is involved in acquisition of conditioned odor preferences in neonatal animals, in some species-specific odor-dependent behaviors, and in adult odor perception. We provide a detailed review of the functional role of NE in adult rodent main olfactory bulb function. We include cellular, synaptic, network, and behavioral data and use computational simulations to tie these different types of data together.
منابع مشابه
Noradrenergic and cholinergic modulation of olfactory bulb sensory processing
Neuromodulation in sensory perception serves important functions such as regulation of signal to noise ratio, attention, and modulation of learning and memory. Neuromodulators in specific sensory areas often have highly similar cellular, but distinct behavioral effects. To address this issue, we here review the function and role of two neuromodulators, acetylcholine (Ach) and noradrenaline (NE)...
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متن کاملFunctional differentiation of cholinergic and noradrenergic modulation 2 in a biophysical model of olfactory bulb granule cells
28 Olfactory bulb granule cells are modulated by both acetylcholine (ACh) and norepinephrine 29 (NE), but the effects of these neuromodulators have not been clearly distinguished. We used 30 detailed biophysical simulations of granule cells, both alone and embedded in a microcircuit with 31 mitral cells, to measure and distinguish the effects of ACh and NE on cellular and microcircuit 32 functi...
متن کاملTitle : Non - linear effects of noradrenergic modulation of olfactory bulb function in 1 adult
14 The mammalian main olfactory bulb (MOB) receives a significant noradrenergic 15 input from the locus coeruleus. Norepinephrine (NE) is involved in acquisition of 16 conditioned odor preferences in neonatal animals, in some species-specific odor 17 dependent behaviors and in adult odor perception. We here provide a detailed review of 18 the functional role of norepinephrine in adult rodent ma...
متن کاملAction of the noradrenergic system on adult-born cells is required for olfactory learning in mice.
We have previously shown that an experience-driven improvement in olfactory discrimination (perceptual learning) requires the addition of newborn neurons in the olfactory bulb (OB). Despite this advance, the mechanisms which govern the selective survival of newborn OB neurons following learning remain largely unknown. We propose that activity of the noradrenergic system is a critical mediator p...
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ورودعنوان ژورنال:
- Journal of neurophysiology
دوره 105 4 شماره
صفحات -
تاریخ انتشار 2011